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Pittsburgh Pirates
Pittsburgh Pirates8th in MLB (79-77)
VS
St.Louis Cardinals
St.Louis Cardinals10th in MLB (76-80)

Pittsburgh Pirates vs St.Louis Cardinals

Wednesday, Sep 23, 2026 · --:--

Pittsburgh Pirates Arena

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AI Confidence: 55%
Pittsburgh Pirates55%St.Louis Cardinals45%

AI Predicted Winner

Pittsburgh Pirates

55%

#Confidence

Compare Odds

No odds data available for this match.

BetYouCanWin does not process real bets. For entertainment purposes only.

AI Match Analysis

Pittsburgh hosts St. Louis in a late-September National League matchup between two clubs already out of playoff contention, but home-field form and a favorable pitching matchup still give the Pirates a slight edge. Jared Jones takes the mound for Pittsburgh against Matthew Liberatore, and that pairing is the central driver behind the home side's advantage in this one.

Bryan Reynolds has a strong track record against Liberatore, and with Oneil Cruz providing pop in the middle of the order, Pittsburgh's offense should have enough traffic on the bases to capitalize. St. Louis counters with a competent rotation arm in Liberatore, but the Cardinals' lineup construction hasn't shown the same consistent edge against Jones-type stuff this season. A minor bench rotation involving Mangum sitting doesn't shift the underlying matchup dynamics in any meaningful way.

With both teams eliminated from postseason contention, motivation levels are roughly even, which keeps the focus squarely on the pitching matchup and recent batter-versus-pitcher history rather than external incentives. That statistical framework supports Pittsburgh as the more likely winner in a game expected to be competitive rather than lopsided.

For bettors, the Pirates as home favorites make sense given the Jones-Liberatore matchup and Reynolds' history, though the tight percentage split (55-45) suggests value may lean toward moderate-stakes plays on Pittsburgh moneyline rather than heavy run-line exposure. Total runs markets could also be worth monitoring given both bullpens' late-season workloads.

Key Factors

Home Advantage

Moderate

Recent Form

Strong

H2H Record

Even

Injury Impact

Low

Season Overview

2026 Season

Record
Pittsburgh Pirates79-7750.6%
St.Louis Cardinals76-8048.7%
Runs Scored
Pittsburgh Pirates4.8
St.Louis Cardinals4.5
Runs Allowed
Pittsburgh Pirates4.6
St.Louis Cardinals4.7
Run Differential
Pittsburgh Pirates+0.2
St.Louis Cardinals-0.2

More Predictions

All statistics and predictions are for informational purposes only. Please gamble responsibly.

Last 10 head-to-head matchups

Pittsburgh Pirates (4)St.Louis Cardinals (6)
Aug 30, 26
(H)St.Louis Cardinals4 - 5Pittsburgh Pirates(A)
A
Aug 29, 26
(H)St.Louis Cardinals2 - 6Pittsburgh Pirates(A)
A
Aug 29, 26
(H)St.Louis Cardinals4 - 1Pittsburgh Pirates(A)
H
May 21, 26
(H)St.Louis Cardinals2 - 6Pittsburgh Pirates(A)
A
May 20, 26
(H)St.Louis Cardinals0 - 7Pittsburgh Pirates(A)
A
May 19, 26
(H)St.Louis Cardinals9 - 6Pittsburgh Pirates(A)
H
Apr 30, 26
(H)Pittsburgh Pirates5 - 10St.Louis Cardinals(A)
A
Apr 29, 26
(H)Pittsburgh Pirates4 - 5St.Louis Cardinals(A)
A
Apr 28, 26
(H)Pittsburgh Pirates7 - 11St.Louis Cardinals(A)
A
Apr 27, 26
(H)Pittsburgh Pirates2 - 4St.Louis Cardinals(A)
A

Expert H2H Analysis

AI Insight

St. Louis has dominated the recent head-to-head sample, winning 6 of the last 10 meetings between these clubs, including a...

St. Louis has dominated the recent head-to-head sample, winning 6 of the last 10 meetings between these clubs, including a four-game sweep-style run in late April on the road. However, Pittsburgh clawed back with two home wins in the August series. The Cardinals have shown they can score in bunches against Pittsburgh, with several double-digit run games in this matchup, suggesting an Over-friendly total tendency historically between these two clubs.

Last 15 matches across all competitionsMLB matches highlighted

Pittsburgh Pirates

15 of 15 in MLB

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Form Rating

6.7/10

Pittsburgh Pirates Form Analysis

Trending

Pittsburgh has won nine of its last 15 games, riding a strong recent stretch that...

Pittsburgh has won nine of its last 15 games, riding a strong recent stretch that includes sweeping Kansas City and taking two of three from Milwaukee. The Pirates are scoring 5.2 runs per game at home this season against 4.9 allowed, a solid differential that supports their current form surge. Their record sits at 79-77 overall (42-36 at home), and the recent form shows resilience even after some rough patches against the Cubs. With rest at three days and no fatigue concerns, Pittsburgh enters this matchup with momentum and a favorable home run-scoring environment working in its favor.

St.Louis Cardinals

15 of 15 in MLB

W
L
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L
L
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L
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L
L
L
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Form Rating

4/10

St.Louis Cardinals Form Analysis

Analysis

St. Louis has struggled recently, losing seven of its last 15 games, including back-to-back losses...

St. Louis has struggled recently, losing seven of its last 15 games, including back-to-back losses to Washington and a rough series against San Francisco where they allowed double-digit runs twice. The Cardinals sit at 76-80 overall with a negative run differential (-23), and their home splits this season (38-43, 3.8 runs scored) have been notably weaker than their road numbers (5.3 runs scored). Despite the recent skid, St. Louis has shown flashes of offense, scoring 5+ runs in several recent outings. Rest is not a concern at three days, but the current form trend clearly favors Pittsburgh heading into this contest.

info

No injury information available for baseball

Player availability isn't provided by our data source for this sport.

Pittsburgh Pirates vs St.Louis Cardinals - Match Analysis

Who wins Pittsburgh Pirates vs St.Louis Cardinals?

Pittsburgh holds the edge based on significantly better recent form, a stronger home run-scoring environment (5.2 runs/game at home), and a two-spot lead in the standings. St. Louis has dropped seven of its last 15 games and struggled defensively at home. While the PPG gap is razor-thin, momentum favors the Pirates as moderate favorites in this matchup.

Should I take St. Louis on the +1.5 run line?

Yes, the Cardinals +1.5 offers more cushion than backing them outright on the moneyline. Even during their recent slide, St. Louis has kept several games within a run or two, and their road offense (5.3 runs/game) gives them scoring punch. This makes +1.5 a higher-probability play than betting on a straight-up upset.

Will this game go over or under the runs total?

Both teams have combined for several high-scoring affairs recently, including multiple games with 8+ combined runs in their head-to-head series this season. With no confirmed elite starters and both bullpens showing recent cracks, particularly St. Louis's staff, the Over looks like the more attractive lean based on the scoring trends from both clubs' last 15 games.

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